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Service Centre

Solid State Characterization

Hovione FarmaCiencia SA

Service Centre category(ies)

Spectrometry / Crystallography

Description of the Service Centre

Solid state chemistry in its broadest manifestation involves using the crystal structure and solid state analytical information to explain solid-state properties, which is crucial to develop new drugs. At Hovione, the mission of the group is to collaborate with customers in the field of solid state, particularly in the characterization of solid phases of raw materials to finished products, from API to drug products in all stages of development and production. Innovation is continuously promoted.

Service Centre web address

www.hovione.com

Contact person's name

Constança Cacela

Contact person's e-mail

ccacela @hovione.com

Contact person's telephone

+351 219 829 359

Services

Service

Solid State Characterization - Chemistry

Available for external use?

No

Comments

1) Characterization and stability of polymorphs; 2) Phase transformations; 3) Characterization of Solvates and hydrates. 4) Screening and selection of polymorphs.

Service

Solid State Characterization - Particle design

Available for external use?

No

Comments

Amorphous forms and solid dispersions: screening, stability and selection; glass transition temperatures; relaxation studies.

Service

Particle Characterization

Available for external use?

No

Comments

Morphology, particle size determination, fine tune of particle size, stabilization of nanoparticles.

Service

Methods development and validation

Available for external use?

No

Comments

1 Detection and quantitation of solid phases in API, drug products, tablets and capsules. 2 Problem solving and development studies. 3 Methods (DSC, TGA, PSD, XRPD): transfers, qualifications, reduced and full validations.

Equipments

Equipment

X-Ray Powder Diffractometer (XRPD), X´Pert Pro, PANalytical

Service type: self-service or full-service?

Full-service

Equipment

Differential Scanning Calorimeter (DSC), Q200, TA instruments

Service type: self-service or full-service?

Full-service

Equipment

Thermal Gravimetric Analyser (TGA), Q500, TA instruments

Service type: self-service or full-service?

Full-service

Equipment

Fourier Transform Infrared Spectroscopy (FTIR), Avatar 360, Nicolet

Service type: self-service or full-service?

Full-service

Equipment

Microscope, BA310 Series, Motic

Service type: self-service or full-service?

Full-service

Comments

Microscope with polarizer and camera (Moticam 2500, Motic)

Equipment

Other in-house available techniques: NIR, DVS and hot stage microscopy

Service type: self-service or full-service?

Full-service

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