Service Centre category(ies)
Animal Facilities / Research Animals
Description of the Service Centre
Expertus, in vivo CAM assays is a spin-off of IPATIMUP that supplies a range of innovative custom made chicken embryo CAM (choriallantoic membrane) assays, as services for cancer research and anti-cancer drug screening. Specifically, CAM assays for the evaluation of angiogenesis (induced by cells and/or drugs), tumorigenesis and invasion.
Service Centre web address
Contact person's name
Marta Teixeira Pinto
Contact person's e-mail
mtpinto@ipatimup.pt; martapinto@expertus.pt
Contact person's telephone
351225570700
Last edited on
2014-02-05 15:16:11
Service
ResearchAssess
Available for external use?
Yes
Comments
The service is designed for researchers (and CROs - contract research organizations) who need in vivo validation of their in vitro results. It is intended to validate cancer target molecules (genes; proteins; etc) in an in vivo context. It is a low cost and time effective assay and constitutes a valuable tool to evaluate complex cancer features - cancer induced-angiogenesis, tumor growth, invasion, etc - of genetically modified cancer cell lines grown in culture. Assays are fine-tuned for each experiment. A preliminary assay allows the optimization of several parameters such as the number of cells to inoculate or drug concentration, inoculation and end points times and best fitted validation methods and strategies.
Service
DrugAssess
Available for external use?
Yes
Comments
The service is designed for pre-clinical studies. The DrugAssess service is targeted for in vivo drug screening previous to tests in rodents in order to reduce and refine the lead compounds entering tests in mammals. Assays are fine-tuned for each experiment, by previous optimization of specific parameters.
Equipment
Stereomicroscope (Olympus); Egg Incubators
Service type: self-service or full-service?
Full-service
Comments
Full-service (Cell lines and/or drugs provided by the client) Full service includes the in vivo assay (animal preparation, data collection and analysis of results, discussion and writing. Additional validation of the results (eg: histological analysis) is an option.