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Service Centre

Bn'ML-Behavioral and Molecular Lab

Life and Health Science Research Institute (ICVS)

Service Centre category(ies)

Animal Facilities / Research Animals

Description of the Service Centre

Bn’ML company provides behavioral and molecular analysis services for both the academia and industry to assess the therapeutic potential of new compounds, using animal models of disease. Our services include: a flexible design of the study to evaluate the therapeutic potential of new compounds; the induction of the disease symptoms in animals; the administration of the compounds in animals; the evaluation of the therapeutic potential of the compounds at the behavioral and molecular levels.

Service Centre web address

http://www.bnml.eu

Contact person's name

Luísa Pinto

Contact person's e-mail

luisapinto@ecsaude.uminho.pt; luisapinto@bnml.eu

Contact person's telephone

966778306 / 253 604947

Last edited on

2013-07-26 15:22:30

Services

Service

Consulting/scientific advice

Available for external use?

Yes

Comments

In addition to the behavioral and molecular analysis services for assessing the therapeutic potential of new compounds, Bn´ML provides scientific advice within the development of new therapeutic solutions impacting on neurological, neurodegenerative and n

Service

Behavioral and Molecular analysis services

Available for external use?

Yes

Comments

The Bn’ML provides state of the art facilities as well as services of experimental design, optimization and execution of in vivo experimentation in different animal models of disease (such as neuropsychiatric and neurodegenerative disorders).

Equipments

Equipment

Molecular analyses equipments

Service type: self-service or full-service?

Full-service

Comments

Gene expression, by RT-PCR or PCR arrays; Tri-dimensional morphological analysis of neurons by Golgi-Cox staining or Immuno-Golgi (to label newborn neurons - patented by Bn´ML); Neuronal and Glial markers analysis by immunohistochemistry, immunofluorescence, ELISA and Western-Blot; Glucocorticoids levels assessment; Cytokines profiling analysis; Neuronal activation analysis; Cellular proliferation, neurogenesis and gliogenesis analysis; In vivo cell fate analyses using viral vectors stereotaxic injections DNA methylation profiling analysis; In vitro assays:Cytotoxicity and cell death; Cellular viability; Cellular proliferation; Cellular differentiation.

Equipment

Behavioral analyses equipments

Service type: self-service or full-service?

Full-service

Comments

Open Field Test; Rotarod; Water Maze; Radial Arm Maze Object; Place Recognition Task; T Maze; 5-Hole; Elevated Plus Maze; Novelty Suppressed Feeding Test; Open Field Test; Pre-pulse inhibition; Acoustic Startle; Light / Dark box; Paw/tail flick test; Hot/Cold plate test; VonFrey Filaments test; Paw Pressure Test; Sucrose Preference test; Forced Swimming test; Tail Suspension test;

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