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Service Centre

Rodon Biologics

Rodon Biologics

Service Centre category(ies)

Cell Analysis / Flow Cytometry
Cell Culture and Manipulation
Molecular fractionation, isolation, purification and production

Description of the Service Centre

Rodon Biologics is a service provider company with more than 15 years experience in protein recombinant production andprocess development. Rodon is a spin-off of Biotecnol, a company operating in Portugal since 1996 dedicated to biological development. Rodon services include: protein production, analytical characterization, cell-based assays, cell line and process development. Rodon is customer-centric and guarantees that the projects are executed under a quality system.

Service Centre web address

www.rodonbiologics.com

Contact person's name

Ana Rita Ricardo

Contact person's e-mail

arr@rodonbiologics.com

Contact person's telephone

351214220520

Last edited on

2018-02-27 16:02:50

Services

Service

Analytical characterization

Available for external use?

Yes

Comments

At Rodon we have the experience to develop and execute the required analytical procedures to assure product and process quality. Tests are designed in consideration of the relevant Pharmacopoeia (EU and US monographs) and regulatory guidelines (ICH, FDA and EMEA) and considering GMP practices.

Service

Cell line development

Available for external use?

Yes

Comments

Rodon’s cell line development activities are performed as a stand-alone service or are fully integrated into a process development program. Rodon can create vectors to express product using CHO platform. Protein yields of grams-per-liter range have been achieved using this system in chemically defined, animal-, component-free medium. This procedure is based on a simple workflow which allows obtaining a high-producing single cell clone in 13-18 weeks. Moreover, once a high producing pool is generated, the quality of the material is evaluated and it can be used to produce gram-per-liter quantities of material in 8-11 weeks.

Service

Cell-based assays

Available for external use?

Yes

Comments

Bioassays are one of the few analytical tools where native proteins can be characterized in vitro, under physiological conditions. They are essential in assuring integrity and functionality of a biological product. Our expertise includes the setting of binding, proliferation, cytotoxic and viral assays. At Rodon these types of bioassays are implemented and carried out on a routine basis in biosafety level 2 laboratory facilities, against suitable controls, and wherever possible International Reference Standards.

Service

Process development

Available for external use?

Yes

Comments

Rodon has extensive experience with both microbial (E.coli, yeast) and mammalian cell culture derived proteins. Using our proprietary and in-licensed technology for expression proteins are rapidly screened in different constructs, to identify the most suitable system, using tightly-regulated inducible promoters for microbial cells. For each protein cloned, a careful development program is carried out in order to study in detail, optimal protocols based on the protein characteristics, process steps and conditions. The process optimization is performed in parallel with the DSP process development in order to obtain a global high yielding and high quality process. Process development programme is also cost effective, robust and transferable driven.

Service

Recombinant protein production

Available for external use?

Yes

Comments

Rodon\'s custom recombinant protein services comprise a portfolio of recombinant protein expression systems that include bacteria, yeast and mammalian cells. Our company offers a full spectrum of recombinant protein purification methods to achieve the ideal level of purity for research purposes. With customized solutions and flexible production scale we work in partnership with our clients to ensure efficient and high quality recombinant protein production, process development and scale-up production of biologics.

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