Science and Technology Resources Database, SciPort

2012 ASPIRE Young Investigator Research Awards in Endocrinology - Laboratórios Pfizer, Lda
Disciplines: Endocrinology and metabolism (including diabetes, hormones)
Principal R&D Unit: Pfizer Medical

Keywords: Endocrinology; research; research award

A role for Nrf2/ARE cytoprotective signalling in iron overload. Adaptive response to oxidative stress as a disease modifier in HFE associated hereditary hemochromatosis - IBMC - Institute for Molecular and Cell Biology
Disciplines: Pharmacology and pharmacy
Principal R&D Unit: Iron and Innate Immunity

Keywords: iron, hemochromatosis, antioxidant, oxidative stress, Nrf2

Analysis of the molecular and cellular function of SteA, a Salmonella virulence protein - Instituto de Tecnologia Química e Biológica
Disciplines: Other biological topics
Principal R&D Unit: Instituto de Tecnologia Química e Biológica

Keywords: Salmonella Type III secretion Effectors Membrane traffic

Application of combined bioinformatic and experimental approaches to elucidate a clinical preeclamsia management strategy - IBMC - Institute for Molecular and Cell Biology
Disciplines: Reproductive biology (medical aspects go to scientific area 3.n)
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: Preeclampsia, bioinformatics, pregnancy hypertension

Assisted Living - Critical Health, S.A.
Disciplines: Computer sciences, information science and bioinformatics (hardware development go to scientific area 2.2, social aspect to be 5.8)
Principal R&D Unit: Health Monitoring

Keywords: Assisted Living, Pacients monitoring, vital signs

BIA 5 - 1058 - BIAL - Portela & Cª, S.A.
Disciplines: Pharmacology and pharmacy
Principal R&D Unit: Prof. Patrício Soares-da-Silva

Keywords: BIA 5-1058, Cardiovascular Diseases, dopamine ß-hydroxylase

BIA 9 - 1067 (Opicapone) - BIAL - Portela & Cª, S.A.
Disciplines: Neurosciences (including psychophysiology)
Principal R&D Unit: Prof. Patrício Soares-da-Silva

Keywords: BIA 9-1067, Opicapone, Parkinson Disease, COMT, Levodopa

Characterisation of host cell pathways altered by effectors of Brucella, Chlamydia, and Coxiella: identification of novel therapeutic targets - Instituto de Tecnologia Química e Biológica
Disciplines: Other biological topics
Principal R&D Unit: Instituto de Tecnologia Química e Biológica

Keywords: Bacterial pathogenesis Chlamydia Chlamydia Effectors Type III Secretion

Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury - IBMC - Institute for Molecular and Cell Biology
Disciplines: Neurosciences (including psychophysiology)
Principal R&D Unit: Nerve Regeneration

Keywords: spinal cord injury, axonal regeneration

Development of new macrocyclic bifunctional chelators for metalloradiopharmaceuticals - Instituto de Tecnologia Química e Biológica
Disciplines: Organic chemistry
Principal R&D Unit: Instituto de Tecnologia Química e Biológica

Keywords: Bifuncional chelators; cross-bridged tetraaza derivatives; thermodynamic constants; kinetics studies; metalloradiopharmaceutic drug

Dry Powder Inhaler Device Development - Hovione FarmaCiencia SA
Disciplines: Health care sciences and services (including hospital administration, health care financing)
Principal R&D Unit: Hovione FarmaCiencia SA

Keywords: DPI, Device, Inhaler, design, moulding, Dry Powder

Endocannabinoids as lipid mediators in reproduction - IBMC - Institute for Molecular and Cell Biology
Disciplines: Reproductive biology (medical aspects go to scientific area 3.n)
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: endocannabinoids, pregnancy, anandamide

Endocannabinoids as lipid mediators in reproduction - IBMC - Institute for Molecular and Cell Biology
Disciplines: Toxicology, Pharmacology and pharmacy
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: endocannabinoids, pregnancy, anandamide

Eslicarbazepine acetate - Epilepsy treatment in pediatric patients - BIAL - Portela & Cª, S.A.
Disciplines: Neurosciences (including psychophysiology)
Principal R&D Unit: Prof. Patrício Soares-da-Silva

Keywords: Eslicarbazepine acetate, Epilepsy, Pediatric, Adjunctive therapy

Eslicarbazepine acetate, Monotherapy - BIAL - Portela & Cª, S.A.
Disciplines: Neurosciences (including psychophysiology)
Principal R&D Unit: Prof. Patrício Soares-da-Silva

Keywords: Eslicarbazepine acetate, Epilepsy, Monotherapy

Genetic predisposition versus the effect of regular physical exercise on circulating adipokine levels in obese Portuguese adolescents - IBMC - Institute for Molecular and Cell Biology
Disciplines: Sport and fitness sciences, Public and environmental health
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: Adipokines, adolescent obesity, regular physical exercise, genetic polymorphisms

Genetic predisposition versus the effect of regular physical exercise on circulating adipokine levels in obese Portuguese adolescents - IBMC - Institute for Molecular and Cell Biology
Disciplines: Human genetics
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: Adipokines, adolescent obesity, regular physical exercise, genetic polymorphisms

Glycosylation and Lewis X motif in neuronal tissue - Instituto de Tecnologia Química e Biológica
Disciplines: Infectious diseases
Principal R&D Unit: Instituto de Tecnologia Química e Biológica (ITQB/UNL)

Keywords: Lewis X; neuron adhesion; fucosyltransferase 9; neurite outgrowth

Inhalation Drug Product Development - Hovione FarmaCiencia SA
Disciplines: Health care sciences and services (including hospital administration, health care financing)
Principal R&D Unit: Hovione FarmaCiencia SA

Keywords: Inhalation, development, formulation, drug product, pulmonary, dry powder inhalation, particle engineering, dpi,

INSPIIRE - Integrated System for Pfizer Investigator Initiated Research - Laboratórios Pfizer, Lda
Disciplines: Other clinical medicine subjects, Oncology, Clinical neurology, Paediatrics, Endocrinology and metabolism (including diabetes, hormones), Respiratory systems, Rheumatology, Cardiac and Cardiovascular systems
Principal R&D Unit: Pfizer Medical

Keywords: Investigator initiated research; compound transfer program; research

Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach - Instituto de Tecnologia Química e Biológica
Disciplines: Organic chemistry
Principal R&D Unit: Instituto de Tecnologia Química e Biológica

Keywords: Hemagglutinin, virus, fusion peptide, Molecular modelling

METAL (IRON AND ZINC) METABOLISM IN LEISHMANIA - IBMC - Institute for Molecular and Cell Biology
Disciplines: Biochemistry and molecular biology
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatid; parasite; trypanothione; redox; drug development.

METAL (IRON AND ZINC) METABOLISM IN LEISHMANIA - IBMC - Institute for Molecular and Cell Biology
Disciplines: Parasitology, Infectious diseases, Tropical medicine
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatid; parasite; trypanothione; redox; drug development.

Microarray-based detection of antibiotic resistance and virulence factors genes of Escherichia coli and Salmonella spp. isolated from food-producing animals and processed food - Faculty of Pharmacy, University of Coimbra
Disciplines: Cell biology, Microbiology
Principal R&D Unit: Center for Pharmaceutical Studies

Keywords: Microarrays, Antibiotic resistance, Virulence factors, Food safety

Mitochondria: a Biosensor to Investigate Drug-induced Mitochondrial Toxicity - Center for Neuroscience and Cell Biology
Disciplines: Toxicology
Principal R&D Unit: Center for Neuroscience and Cell Biology

Keywords: Cardiotoxicity, hepatotoxicity, mitochondria, drug safety, environmental toxicity

New enzyme inhibitors for breast and prostate cancers: insights to overcome bone loss and endocrine resistance - IBMC - Institute for Molecular and Cell Biology
Disciplines: Pharmacology and pharmacy, Medicinal chemistry
Principal R&D Unit: Biology of Inflammation and Reproduction

Keywords: aromatase inhibitors; breast cancer; apoptosis; autophagy; MCF-7 aro; LTED aro; SAR studies, endocrine resistance

Pneumo Y – Pneumococcal colonization patterns in young children living in urban and rural areas of Portugal in the era of the 13-valent conjugate vaccine. - Instituto de Tecnologia Química e Biológica
Disciplines: Other biological topics
Principal R&D Unit: Instituto de Tecnologia Química e Biológica (ITQB)

Keywords: --

Pneumococcal colonization patterns in the elderly living urban and rural areas of Portugal - Instituto de Tecnologia Química e Biológica
Disciplines: Other biological topics
Principal R&D Unit: Instituto de Tecnologia Química e Biológica (ITQB)

Keywords: --

Pre-clinical assays of a GAPDH-based vaccine against Group B Streptococcus infection - IBMC - Institute for Molecular and Cell Biology
Disciplines: Immunology
Principal R&D Unit: Immunobiology

Keywords: Group B Streptococcus; vaccine; GAPDH; neonatal

Role of the yeast neutral sphingomyelinase in mitochondria function and iron homeostasis - IBMC - Institute for Molecular and Cell Biology
Disciplines: Biochemistry and molecular biology
Principal R&D Unit: Redox Cell Signalling

Keywords: Sphingolipids; Mitochondria; Apoptosis; Iron

Significance of the Leishmania infantum mitochondrial 2-cysteine peroxiredoxin chaperone activity and its role in parasite infectivity - IBMC - Institute for Molecular and Cell Biology
Disciplines: Biochemistry and molecular biology
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; parasite; trypanosomatids; 2-cysteine peroxiredoxin; chaperone

Significance of the Leishmania infantum mitochondrial 2-cysteine peroxiredoxin chaperone activity and its role in parasite infectivity. - IBMC - Institute for Molecular and Cell Biology
Disciplines: Parasitology, Infectious diseases, Tropical medicine
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; parasite; trypanosomatids; 2-cysteine peroxiredoxin; chaperone

Study of the immune response and protective effect against neosporosis elicited by mucosal immunization with Neospora caninum antigens - IBMC - Institute for Molecular and Cell Biology
Disciplines: Others
Principal R&D Unit: Immunobiology

Keywords: Neospora caninum; vaccine

THIOL METABOLISM IN LEISHMANIA AND ITS POTENTIAL USE FOR LEISHMANIASIS THERAPY - IBMC - Institute for Molecular and Cell Biology
Disciplines: Biochemistry and molecular biology
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatids; parasite; trypanothione; redox; drug development

THIOL METABOLISM IN LEISHMANIA AND ITS POTENTIAL USE FOR LEISHMANIASIS THERAPY - IBMC - Institute for Molecular and Cell Biology
Disciplines: Tropical medicine, Parasitology, Infectious diseases
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatids; parasite; trypanothione; redox; drug development.

Tracking the evolution of methicilin resistance in staphylococci: stages in the evolution of the mecA determinant and the SCCmec structure - Instituto de Tecnologia Química e Biológica
Disciplines: Evolutionary biology
Principal R&D Unit: Instituto de Tecnologia Química e Biológica (ITQB)

Keywords: methicillin resistance, evolution, Staphylococcus, mecA, staphylococcal cassette chromosome mec (SCCmec)

Trypanosomatid 2- cys peroxiredoxins and their role in virulence - IBMC - Institute for Molecular and Cell Biology
Disciplines: Biochemistry and molecular biology
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatids; parasite; infection; c-cys peroxiredoxin.

Trypanosomatid 2- cys peroxiredoxins and their role in virulence - IBMC - Institute for Molecular and Cell Biology
Disciplines: Parasitology, Infectious diseases, Tropical medicine
Principal R&D Unit: Molecular Parasitology

Keywords: Leishmania; Trypanosomatids; parasite; infection; c-cys peroxiredoxin.

Understanding the contribution of iron overload in non-alcoholic fatty liver disease: identification of cellular players and potential molecular therapeutic targets - IBMC - Institute for Molecular and Cell Biology
Disciplines: Pathology
Principal R&D Unit: Iron and Innate Immunity

Keywords: iron, liver, non-alcoholic fatty liver disease, steatohepatitis

Unravelling pneumococcal interactions in the nasopharyngeal niche - Instituto de Tecnologia Química e Biológica
Disciplines: Other biological topics
Principal R&D Unit: Instituto de Tecnologia Química e Biológica (ITQB)

Keywords: --

Ver+Saúde - Critical Health, S.A.
Disciplines: Medical laboratory technology (including laboratory samples analysis; diagnostic technologies)
Principal R&D Unit: Vision Unit

Keywords: Diabetic Retinopathy; Radial Distortion Correction; Glaucoma;

Zebinix® (Eslicarbazepine acetate) - Epilepsy treatment in adult patients - BIAL - Portela & Cª, S.A.
Disciplines: Neurosciences (including psychophysiology)
Principal R&D Unit: Prof. Patrício Soares-da-Silva

Keywords: Eslicarbazepine acetate, Epilepsy, Adjunctive therapy