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Sequencing Service  -  IPATIMUP
The sequencing service serves investigators and technicians who develop their work at IPATIMUP. This service is accountable for maintaining and handling the automated sequencers present at IPATIMUP facilities. This service includes the automated analysis of PCR and sequencing products (GeneMapper and Sequencing Analysis, respectively), by organizing the samples delivered on each day and distributing them through the appropriate instrument. It also performs sequencing reactions and its analysis.
Its mission is to provide optimal services of surgical pathology and cytopathology, molecular pathology, genetic diagnosis, and parentage and genetic identification. This Unit is accredited by the College of American Pathologists, while it is enrolled in other Quality Control Programs. It has state-of-the-art equipment, namely a Next Generation platform. It is a reference center for several pharmaceutical companies for specific analysis and works with most of the main Portuguese Hospitals.
Cell Culture and Genotyping  -  IBMC - Institute for Molecular and Cell Biology
Cooperates with researchers to improve cell culture conditions, genotyping, gene expression techniques and offers technical assistance to researchers. Offers individual fully equipped and monitored rooms for cell culture, mycoplasma tests and a monitored N2 reservoir for cell storage. Facilitates the implementation of genotyping and gene expression technology including expert consultation and training, by providing equipment for gene expression analysis; automated DNA and RNA extraction; quantif
Center for Predictive and Preventive Genetics  -  IBMC - Institute for Molecular and Cell Biology
At the outpatient clinic, patients and families with genetic diseases are observed and counselled by a multi-disciplinary team. At our molecular genetics lab, diagnostic, carrier, presymptomatic and prenatal tests are available for a large number of diseases. A quality management system is in place, and a formal request for accreditation has already been filed to IPAQ. The DNA/cell-line bank storages many thousands of samples, coupled with clinical and pedigree data.
Laboratory of Support to Research in Molecular Medicine (LAIMM)  -  Faculdade de Medicina da Universidade do Porto
The Laboratory of Support to Research in Molecular Medicine was created to promote the development of medical research. It offers logistical, operational and consulting services in the context of biomedical research projects, as well as custom molecular biology laboratory services, mutant and transgenic mouse models production, and scientific training.
Assay Development Unit  -  BIOALVO SA
BIOALVO developed a proprietary bioactive discovery technology based on the use of yeast as a model organism–Global Platform Screening for Drug Discovery (GPS D2). This technology is extremely flexible and customizable. Depending on the desired activity, new assays can be developed for the identification of new ingredients/molecules with proven potency and safety.BIOALVO has already implemented assays for a wide range of markets, such as cosmetic, pharmaceutical, nutrition and household products
GMP Manufacturing - Cells and Cell based Products  -  Stemmatters, Biotecnologia e Medicina Regenerativa SA
Stemmatters provides cGMP services regarding tissue processing, manufacturing and banking (cells and cell based products).The facility comprises 250 m2 of qualified controlled environment rooms (CERs) and material pass-boxes. Our quality management system ensures that our products are consistently produced and controlled according to strict quality standards (EU-GMP Guide/ICH Q7 and ISO 9001:2008).We work with specialized distribution networks to assure high quality according to GMP guidelines.
GENOINSEQ  -  BIOCANT - Biotechnology Innovation Center
Genoinseq grants access to the full potential of state-of-the-art of next generation sequencing equipment, high throughput genotyping and bioinformatics data analysis. Genoinseq provides services or collaborates in R&D projects with companies and research groups. The unit has a multidisciplinary team of experts in sequencing and bioinformatics, delivering personalized solutions, from consultancy in experimental design to large scale data analysis with user-friendly outputs.
Cell Biology  -  iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
This facility is dedicated to the analysis of gene expression at DNA, RNA and protein level, routinely performing a multitude of biochemical and molecular biology techniques using standard equipment for electrophoresis, western blot, northern bot, as well absorbance plate reader, and gel, membrane and X-ray film imaging (Chemidoc MP and XRS; Bio-Rad).
Cell Function  -  iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
The facility is tailored for biological evaluation of cell function, routinely determining cytotoxic and cytoprotective activities of synthetic and natural compounds, in multiple cell models, including immortalized and primary cultures and stem cells, with implemented capability of cell function assays up to 96 and 384-well format.
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