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mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Center for Neuroscience and Cell Biology
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Physiology (including cytology)

Project description

Project title

mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Scientific Coordinator's name:

Paulo Oliveira

Scientific Coordinator's e-mail:

pauloliv@ci.uc.pt

Principal R&D Unit:

Center for Neuroscience and Cell Biology

Other R&D Units involved in the project:

BIOCANT

Project keyword(s)

Non-alcoholic fatty liver disease; metabolism; mitochondria; diagnostic tools; biomarker; new therapies; value creation; staff mobility; technology transfer

Short abstract and comments

NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment. mtFOIE GRAS (Foie Gras being French for \"fat liver\") proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers.

Potential uses/indications

mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributing to EU RD&I excellence.

Status

Ongoing

Partner Status: Seeking Partners?

No

Grant number (QREN, FP7, Eureka, etc)

H2020-MSCA-RISE-2016- 734719

Last edited on

2017-03-30 11:00:48

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