Services Centres
Advanced Flow Cytometry Unit -
IBMC - Institute for Molecular and Cell Biology
The AFCU provides investigators with equipment for acquisition and analysis of flow cytometric data and for cell sorting from single cell suspension using fluorescence. Furthermore, the AFCU gives training and consulting for researchers that intend to use flow cytometry in their projects; and helps analyzing and interpreting data. A number of applications, including the multicolour analysis of cell phenotype, gene expression, membrane potential, cell cycle, among others, can be performed.
The AFCU provides investigators with equipment for acquisition and analysis of flow cytometric data and for cell sorting from single cell suspension using fluorescence. Furthermore, the AFCU gives training and consulting for researchers that intend to use flow cytometry in their projects; and helps analyzing and interpreting data. A number of applications, including the multicolour analysis of cell phenotype, gene expression, membrane potential, cell cycle, among others, can be performed.
Advanced Light Microscopy -
IBMC - Institute for Molecular and Cell Biology
The Advance Light Microscopy (ALM) is an open access scientific core facility of IBMC dedicated to state-of the-art optical microscopy applications for biosciences. Multidimensional (6D) imaging of cells and tissues, high speed live cell microscopy, molecular analysis techniques (FRAP, FRET) and in vivo microscopy are some of the applications available to researchers
The Advance Light Microscopy (ALM) is an open access scientific core facility of IBMC dedicated to state-of the-art optical microscopy applications for biosciences. Multidimensional (6D) imaging of cells and tissues, high speed live cell microscopy, molecular analysis techniques (FRAP, FRET) and in vivo microscopy are some of the applications available to researchers
Analytical Service Unit (ASU) -
iBET - Instituto de Biologia Experimental e Tecnológica
ASU combines several services including studies on candidate pharmaceutical products (GLP), as well as analytical development, method validation and testing of chemicals and biologicals for the pharmaceutical, food and chemical industry and academia. ASU includes expertises divided by three laboratories: Analytical Lab, Mass Spectrometry Lab (iBET acess through ITQB which is one of the institutions in the National Network for Massspectometry) and Microbiology and Bioassays Lab
ASU combines several services including studies on candidate pharmaceutical products (GLP), as well as analytical development, method validation and testing of chemicals and biologicals for the pharmaceutical, food and chemical industry and academia. ASU includes expertises divided by three laboratories: Analytical Lab, Mass Spectrometry Lab (iBET acess through ITQB which is one of the institutions in the National Network for Massspectometry) and Microbiology and Bioassays Lab
Animal Facility -
IBMC - Institute for Molecular and Cell Biology
The IBMC/INEB AH is a breeding and experimental facility. The AH holds 2000 cages of rodents and 2 to 4 rabbits. The AH has several strains of genetically modified mice and a considerable part of it are immunocompromised rodents. The AH provides care and maintenance of GMA animais, breeding services, veterinary care and surgical support to the diferent strains and experimental models. Polyclonal antibody production is available.
The IBMC/INEB AH is a breeding and experimental facility. The AH holds 2000 cages of rodents and 2 to 4 rabbits. The AH has several strains of genetically modified mice and a considerable part of it are immunocompromised rodents. The AH provides care and maintenance of GMA animais, breeding services, veterinary care and surgical support to the diferent strains and experimental models. Polyclonal antibody production is available.
Animal House -
Center for Neuroscience and Cell Biology
The Animal House is a shared resource that provides services in laboratory animal experimentation and husbandry, for all CNC and FUMC scientists using animals in their research. The present facility has a capacity to house more than 3000 animals (rats/mice). This facility offers the following services: complete husbandry, including feeding, watering, daily cage changing, as well as routine procurement, inventory and care.
The Animal House is a shared resource that provides services in laboratory animal experimentation and husbandry, for all CNC and FUMC scientists using animals in their research. The present facility has a capacity to house more than 3000 animals (rats/mice). This facility offers the following services: complete husbandry, including feeding, watering, daily cage changing, as well as routine procurement, inventory and care.
Animal Model Facility -
IPATIMUP
All researchers can use these facilities to perform research with animal models. The available mice strain is produced in our Animal House: an immunodeficient mouse model, with combined immunodeficiency in T- and B-cells, which supports the growth of human and animal tumor xenografts. Their main area of application is in tumour biology and xenograft research. For more information please visit www. ipatimup.pt > Diagnostic Services > Animal Model Facility
All researchers can use these facilities to perform research with animal models. The available mice strain is produced in our Animal House: an immunodeficient mouse model, with combined immunodeficiency in T- and B-cells, which supports the growth of human and animal tumor xenografts. Their main area of application is in tumour biology and xenograft research. For more information please visit www. ipatimup.pt > Diagnostic Services > Animal Model Facility
Biostatistics | Pharmacoeconomics -
Eurotrials, Consultores Científicos, S.A.
The department of Bioestatistics provides a wide range of services adapted to the needs of each project. Statistical advice, study reports and assistance in preparing articles for biomedical journals are examples. It also ensures correct methodological development and appropriate planning in clinical trials and guarantees the quality of protocols and reliable data processing, all of which are crucial to the success of any research project.
The department of Bioestatistics provides a wide range of services adapted to the needs of each project. Statistical advice, study reports and assistance in preparing articles for biomedical journals are examples. It also ensures correct methodological development and appropriate planning in clinical trials and guarantees the quality of protocols and reliable data processing, all of which are crucial to the success of any research project.
Cell Culture and Genotyping -
IBMC - Institute for Molecular and Cell Biology
Cooperates with researchers to improve cell culture conditions, genotyping, gene expression techniques and offers technical assistance to researchers. Offers individual fully equipped and monitored rooms for cell culture, mycoplasma tests and a monitored N2 reservoir for cell storage. Facilitates the implementation of genotyping and gene expression technology including expert consultation and training, by providing equipment for gene expression analysis; automated DNA and RNA extraction; quantif
Cooperates with researchers to improve cell culture conditions, genotyping, gene expression techniques and offers technical assistance to researchers. Offers individual fully equipped and monitored rooms for cell culture, mycoplasma tests and a monitored N2 reservoir for cell storage. Facilitates the implementation of genotyping and gene expression technology including expert consultation and training, by providing equipment for gene expression analysis; automated DNA and RNA extraction; quantif
Center for Predictive and Preventive Genetics -
IBMC - Institute for Molecular and Cell Biology
At the outpatient clinic, patients and families with genetic diseases are observed and counselled by a multi-disciplinary team. At our molecular genetics lab, diagnostic, carrier, presymptomatic and prenatal tests are available for a large number of diseases. A quality management system is in place, and a formal request for accreditation has already been filed to IPAQ. The DNA/cell-line bank storages many thousands of samples, coupled with clinical and pedigree data.
At the outpatient clinic, patients and families with genetic diseases are observed and counselled by a multi-disciplinary team. At our molecular genetics lab, diagnostic, carrier, presymptomatic and prenatal tests are available for a large number of diseases. A quality management system is in place, and a formal request for accreditation has already been filed to IPAQ. The DNA/cell-line bank storages many thousands of samples, coupled with clinical and pedigree data.
Chromatography, LC and GC -
Hovione FarmaCiencia SA
The Chromatography Service integrates multidimensional and hyphenated technologies to perform advance Method Development, Method Validation, In process Control and Final product Release analysis, Standard Qualification and Requalification, Impurity Screening and Characterization. All services provided within the Chromatography area are all under current Good Manufacturing Practices and using Full Qualified Analytical Systems.
The Chromatography Service integrates multidimensional and hyphenated technologies to perform advance Method Development, Method Validation, In process Control and Final product Release analysis, Standard Qualification and Requalification, Impurity Screening and Characterization. All services provided within the Chromatography area are all under current Good Manufacturing Practices and using Full Qualified Analytical Systems.
Clinical Trials -
Eurotrials, Consultores Científicos, S.A.
Eurotrials develops and monitors clinical research projects in Europe and Latin America. The team has vast experience in managing studies on both sides of the Atlantic. At the forefront with clinical research sites, we develop the capacity building projects for integration in International Networks of Excellence and R&D platforms.
Eurotrials develops and monitors clinical research projects in Europe and Latin America. The team has vast experience in managing studies on both sides of the Atlantic. At the forefront with clinical research sites, we develop the capacity building projects for integration in International Networks of Excellence and R&D platforms.
Data Management -
Eurotrials, Consultores Científicos, S.A.
The team uses cutting-edge technology in electronic data collection and is more competitive in undertaking projects. The integration of these processes with Eurotrials’ data management system, which has been validated and is in strict compliance with FDA 21 CFR part 11, is an essential asset.
The team uses cutting-edge technology in electronic data collection and is more competitive in undertaking projects. The integration of these processes with Eurotrials’ data management system, which has been validated and is in strict compliance with FDA 21 CFR part 11, is an essential asset.
Drug Product Evaluation -
Hovione FarmaCiencia SA
The Service Centre Drug Product Evaluation performs the analysis of all products that are involved in the processes of drug product production and development, from the Active Pharmaceutical Ingredient (APIs) until the final drug product, for both oral solid dosage forms and inhalation products. This Service also performs development, validation of analytical methods, in process support, analytical support to galenic development and stability studies. The Service provides physical characterization of powders.
The Service Centre Drug Product Evaluation performs the analysis of all products that are involved in the processes of drug product production and development, from the Active Pharmaceutical Ingredient (APIs) until the final drug product, for both oral solid dosage forms and inhalation products. This Service also performs development, validation of analytical methods, in process support, analytical support to galenic development and stability studies. The Service provides physical characterization of powders.
Egg-Lab - in vivo assays -
IPATIMUP
The Egg Lab Service comprises several chick embryo in vivo assays. Specifically, CAM (choriallantoic membrane) assays for the evaluation of angiogenesis (induced by cells and/or drugs), tumorigenesis and metastization.
The Egg Lab Service comprises several chick embryo in vivo assays. Specifically, CAM (choriallantoic membrane) assays for the evaluation of angiogenesis (induced by cells and/or drugs), tumorigenesis and metastization.
Epidemiology & Late Phase Research -
Eurotrials, Consultores Científicos, S.A.
With more than 350,000 individuals included in its studies, Eurotrials is able to meet the specific needs and requirements of an increasingly demanding area. The existence/availability of Epidemiological data and Post-commercialisation Studies data are crucial in validating Scientific, Therapeutic, Economic and Healthcare Policy solutions. Eurotrials uses cutting edge and technologically innovative solutions to gather information and accompanying data about its projects.
With more than 350,000 individuals included in its studies, Eurotrials is able to meet the specific needs and requirements of an increasingly demanding area. The existence/availability of Epidemiological data and Post-commercialisation Studies data are crucial in validating Scientific, Therapeutic, Economic and Healthcare Policy solutions. Eurotrials uses cutting edge and technologically innovative solutions to gather information and accompanying data about its projects.
EVICR.net Coordinating Centre -
AIBILI - Association for Innovation and Biomedical Research on Light and Image
AIBILI is the headquarters and Coordinating Centre of the European Vision Institute Clinical Research Network – EVICR.net. EVICR.net is a network of European Ophthalmological Clinical Research Sites, dedicated to perform clinical research in ophthalmology. EVICR.net is a platform for clinical trial research in ophthalmology in Europe and a useful Industry resource in order to promote the development of new drugs and medical devices.
AIBILI is the headquarters and Coordinating Centre of the European Vision Institute Clinical Research Network – EVICR.net. EVICR.net is a network of European Ophthalmological Clinical Research Sites, dedicated to perform clinical research in ophthalmology. EVICR.net is a platform for clinical trial research in ophthalmology in Europe and a useful Industry resource in order to promote the development of new drugs and medical devices.
Flow Cytometry Unit -
Center for Neuroscience and Cell Biology
The Flow Cytometry Unit provides technical support on flow cytometry. Currently, it is equipped with a Becton Dickinson FACSCalibur cell analyser and a Partec CyFlow Space cell sorter. The cytometry unit provides scientific and technical support for those wishing to use flow cytometry in their studies and is available to all CNC researchers, as well for those external to the CNC, after prior arrangement.
The Flow Cytometry Unit provides technical support on flow cytometry. Currently, it is equipped with a Becton Dickinson FACSCalibur cell analyser and a Partec CyFlow Space cell sorter. The cytometry unit provides scientific and technical support for those wishing to use flow cytometry in their studies and is available to all CNC researchers, as well for those external to the CNC, after prior arrangement.
Histology Shared Technical Facility (HistoSTF) -
Life and Health Science Research Institute (ICVS)
HistoSTF combines several services in the development and execution of specialized histology techniques to industry and academia. The HistoSTF is composed of a team of 3 specialized lab technicians and is fully equipped for providing services in paraffin and methacrylate embedding tissues, frozen and vibratome sectioning and routine stains.
HistoSTF combines several services in the development and execution of specialized histology techniques to industry and academia. The HistoSTF is composed of a team of 3 specialized lab technicians and is fully equipped for providing services in paraffin and methacrylate embedding tissues, frozen and vibratome sectioning and routine stains.
IPATIMUP Diagnostics -
IPATIMUP
The mission of IPATIMUP Diagnostics is to provide optimal services of surgical pathology and cytopathology, molecular pathology, genetic diagnosis, and parentage and genetic identification. This Unit is accredited by the College of American Pathologists, while it is enrolled in other Quality Control Programs. It is a reference center for several pharmaceutical companies for specific analysis and provides services for most of the main Portuguese Hospitals.
The mission of IPATIMUP Diagnostics is to provide optimal services of surgical pathology and cytopathology, molecular pathology, genetic diagnosis, and parentage and genetic identification. This Unit is accredited by the College of American Pathologists, while it is enrolled in other Quality Control Programs. It is a reference center for several pharmaceutical companies for specific analysis and provides services for most of the main Portuguese Hospitals.
Mass Spectrometry Unit -
Center for Neuroscience and Cell Biology
The Unit is specialized in the identification and quantification of proteins from complex samples, identification of post-translational modifications, and identification and quantification of metabolites. It is mainly focused on running R&D projects from both partners, as well as other collaborators (from CNC, Biocant, other R&D institutes and private companies).
The Unit is specialized in the identification and quantification of proteins from complex samples, identification of post-translational modifications, and identification and quantification of metabolites. It is mainly focused on running R&D projects from both partners, as well as other collaborators (from CNC, Biocant, other R&D institutes and private companies).
Microscopy Shared Technical Facility (MicroSTF) -
Life and Health Science Research Institute (ICVS)
MicroSTF coordinates the microscopy equipment of the ICVS and offers confocal and laser microdissection services to industry and academia. The MicroSTF team is composed of a specialized lab technician and is equipped with several conventional light and fluorescence microscopes, plus confocal, laser microdissection and stereology microscopes.
MicroSTF coordinates the microscopy equipment of the ICVS and offers confocal and laser microdissection services to industry and academia. The MicroSTF team is composed of a specialized lab technician and is equipped with several conventional light and fluorescence microscopes, plus confocal, laser microdissection and stereology microscopes.
Microscopy Unit -
Center for Neuroscience and Cell Biology
The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the CNC. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and laser microdissection microscope. All equipment within the Microscopy Unit is available to everyone working in the CNC and guest workers.
The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the CNC. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and laser microdissection microscope. All equipment within the Microscopy Unit is available to everyone working in the CNC and guest workers.
Pharmacovigilance -
Eurotrials, Consultores Científicos, S.A.
Pharmacovigilance plays an essential role in the protection of public health, especially in assessing the risks and benefits of medicinal products. The department works in continuous cooperation with its partners, whether they are small businesses or multinational companies.
Pharmacovigilance plays an essential role in the protection of public health, especially in assessing the risks and benefits of medicinal products. The department works in continuous cooperation with its partners, whether they are small businesses or multinational companies.
Protein Production and Purification Unit -
IBMC - Institute for Molecular and Cell Biology
The Protein Production and Purification Unit (UP3) provides access to state-of-the-art equipment for the expression, purification and biochemical/biophysical analysis of recombinant proteins. This facility provides both scientific and technical expertise, actively participating in the establishment of interdisciplinary research and networking activities involving internal and external research groups.
The Protein Production and Purification Unit (UP3) provides access to state-of-the-art equipment for the expression, purification and biochemical/biophysical analysis of recombinant proteins. This facility provides both scientific and technical expertise, actively participating in the establishment of interdisciplinary research and networking activities involving internal and external research groups.
Proteomics and Mass Spectrometry -
IPATIMUP
IPATIMUP Proteomics Unit provides access to the analysis of different kind of molecules by MALDI mass spectrometry. The Unit is specially focused in the analysis of protein samples from solutions, bands or protein spots from 1D or 2D electrophoresis gels.
IPATIMUP Proteomics Unit provides access to the analysis of different kind of molecules by MALDI mass spectrometry. The Unit is specially focused in the analysis of protein samples from solutions, bands or protein spots from 1D or 2D electrophoresis gels.
Quality -
Eurotrials, Consultores Científicos, S.A.
The Quality department is an independent department made up of a multidisciplinary group of auditors. They have vast experience in quality control and quality assurance, namely GCP audits. In addition to outsourcing, they ensure that the work of the other Eurotrials departments complies with ISO 9001:2008, the legislation in different countries, the rules of good clinical practice (ICH-GCP and GCP Directive) and any other applicable regulations.
The Quality department is an independent department made up of a multidisciplinary group of auditors. They have vast experience in quality control and quality assurance, namely GCP audits. In addition to outsourcing, they ensure that the work of the other Eurotrials departments complies with ISO 9001:2008, the legislation in different countries, the rules of good clinical practice (ICH-GCP and GCP Directive) and any other applicable regulations.
Regulatory Strategy & Affairs -
Eurotrials, Consultores Científicos, S.A.
This department is responsible for the whole process of registering medicines, medical devices, cosmetics and nutritional products. It monitors their life cycle and provides strategic advice and consultancy on regulatory processes.
This department is responsible for the whole process of registering medicines, medical devices, cosmetics and nutritional products. It monitors their life cycle and provides strategic advice and consultancy on regulatory processes.
Research & Development -
Eurotrials, Consultores Científicos, S.A.
Eurotrials has all the competences and experience needed to operate in the development of drugs, biodrugs and medical devices and can analyse projects (ideas and products) and draft plans for strategic and regulatory development. Eurotrials works with different partners in the RTD process: • Biotechnology companies • Pharmaceutical industry • Research groups –institutes, academia, hospitals • Financial groups • Consultancy firms
Eurotrials has all the competences and experience needed to operate in the development of drugs, biodrugs and medical devices and can analyse projects (ideas and products) and draft plans for strategic and regulatory development. Eurotrials works with different partners in the RTD process: • Biotechnology companies • Pharmaceutical industry • Research groups –institutes, academia, hospitals • Financial groups • Consultancy firms
Sequencing Service -
IPATIMUP
The sequencing service serves investigators and technicians who develop their work at IPATIMUP. This service is accountable for maintaining and handling the automated sequencers present at IPATIMUP facilities. This service includes the automated analysis of PCR and sequencing products (GeneMapper and Sequencing Analysis, respectively), by organizing the samples delivered on each day and distributing them through the appropriate instrument. It also performs sequencing reactions and its analysis.
The sequencing service serves investigators and technicians who develop their work at IPATIMUP. This service is accountable for maintaining and handling the automated sequencers present at IPATIMUP facilities. This service includes the automated analysis of PCR and sequencing products (GeneMapper and Sequencing Analysis, respectively), by organizing the samples delivered on each day and distributing them through the appropriate instrument. It also performs sequencing reactions and its analysis.
Slides Digitalization Unit -
IPATIMUP
The Slides Digitalization Unit (UDL) aims to convert histological and cytological glass slides into high-quality and high-resolution digital slides. The UDL provides as well the chance to storage those images in an appropriate server.
The Slides Digitalization Unit (UDL) aims to convert histological and cytological glass slides into high-quality and high-resolution digital slides. The UDL provides as well the chance to storage those images in an appropriate server.
Solid State Characterization -
Hovione FarmaCiencia SA
Solid state chemistry in its broadest manifestation involves using the crystal structure and solid state analytical information to explain solid-state properties, which is crucial to develop new drugs. At Hovione, the mission of the group is to collaborate with customers in the field of solid state, particularly in the characterization of solid phases of raw materials to finished products, from API to drug products in all stages of development and production. Innovation is continuously promoted.
Solid state chemistry in its broadest manifestation involves using the crystal structure and solid state analytical information to explain solid-state properties, which is crucial to develop new drugs. At Hovione, the mission of the group is to collaborate with customers in the field of solid state, particularly in the characterization of solid phases of raw materials to finished products, from API to drug products in all stages of development and production. Innovation is continuously promoted.
SUIM - Service Unit for Interfaces and Macromolecules -
INEB - Instituto de Engenharia Biomédica
SUIM is a facility of INEB - Instituto de Engenharia Biomédica, providing services and technical training to research centers and industry in the areas of interfaces and macromolecules. The facilities include advanced physical, chemical and structural characterization techniques particularly dedicated to the surface analysis of materials, down to the micrometric and nanometric levels. The techniques available: AFM and AFM/ Epi-fluorescence, DLS, FTIR, EKA, Contact Angles, Ellipsometry.
SUIM is a facility of INEB - Instituto de Engenharia Biomédica, providing services and technical training to research centers and industry in the areas of interfaces and macromolecules. The facilities include advanced physical, chemical and structural characterization techniques particularly dedicated to the surface analysis of materials, down to the micrometric and nanometric levels. The techniques available: AFM and AFM/ Epi-fluorescence, DLS, FTIR, EKA, Contact Angles, Ellipsometry.
Teaching and Training -
Eurotrials, Consultores Científicos, S.A.
Eurotrials develops training programs based upon the knowledge that has been accumulated by the several areas of the company. The training areas are developed with a strong practical component and interactivity under the format of: Training Courses | Modules for post graduations or masters | Workshops | Seminaries included in congresses or meetings | Individual trainings. We develop courses tailored to your needs!
Eurotrials develops training programs based upon the knowledge that has been accumulated by the several areas of the company. The training areas are developed with a strong practical component and interactivity under the format of: Training Courses | Modules for post graduations or masters | Workshops | Seminaries included in congresses or meetings | Individual trainings. We develop courses tailored to your needs!
