Project title

Biomimetic/nanobioconjugates flexible platforms for sensitive immunosensing

Scientific Coordinator's name:

Ana Pimenta da Gama da Silveira Viana

Scientific Coordinator's e-mail:

anaviana@fc.ul.pt

Principal R&D Unit:

Centro de Química e Bioquímica (CQB)

Other R&D Units involved in the project:

Institute of Mechanics, Chinese Academy of Sciences (IMECH)

Project keyword(s)

Surface bio-functionalization; immunosensors; semiconducting nanoparticles; optical and electrochemical detection

Short abstract and comments

The major scientific goal of this project is to develop simple and disruptive surface chemistry to push forward the field of biosensing, severely limited by the short shelf-life, reproducibility and portability of the currently used strategies. Regarding the immunosensors development, two main aspects will be optimized: i) the immobilization of a primary antibody on a phospholipid based biomimetic surface; and ii) the signal amplification methodology to detect the target antigen by a secondary antibody. It is expected to develop innovative yet simple approaches to enhance the detection (electrochemical or optical) of these biological events

Potential uses/indications

Development of simple and innovative methodologies to be employed in the building of high sensitive immunosensor platforms to detect any antibody/antigen of interest. Construction of a pre-industrial prototype of a biosensing equipment to detect toxins (e.g OTA or AFLO) with high sensitivity.