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Bridging diabetes type 2 and AD – new multitarget leads

Faculdade de Ciências da Universidade de Lisboa
Project classification

Scientific area

1.4 Chemical sciences

Discipline(s)

Organic chemistry

Project description

Project title

Bridging diabetes type 2 and AD – new multitarget leads

Scientific Coordinator's name:

Amélia Pilar Rauter

Scientific Coordinator's e-mail:

aprauter@fc.ul.pt

Principal R&D Unit:

Centro de Química e Bioquímica (CQB)

Other R&D Units involved in the project:

Eli Lilly (UK), CEDOC -UNL

Project keyword(s)

synthesis; carbohydrate; polyphenol; diabetes type 2; Alzheimer’s disease; mechanisms of action

Short abstract and comments

A lead series of antidiabetic glucosylpolyphenols has been produced. Currently structure-activity relationship studies for target orientation are carried out, together with the investigation of their mechanism(s) of action and the evaluation of compound antiamyloidogenic activity.

Potential uses/indications

Antidiabetic treatment and prevention of Alzheimer’s disease in diabetic patients, who have a higher risk of later developing Alzheimer’s

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

Diagnostic and Drug Discovery Initiative for Alzheimer’s Disease”, Industry-Academia Partnerships an

Last edited on

2016-11-21 18:04:43

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