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New anticancer and potent butyrylcholinesterase purine nucleosides – their role and mechanism of action in brain and cancer

Faculdade de Ciências da Universidade de Lisboa
Project classification

Scientific area

1.4 Chemical sciences

Discipline(s)

Organic chemistry

Project description

Project title

New anticancer and potent butyrylcholinesterase purine nucleosides – their role and mechanism of action in brain and cancer

Scientific Coordinator's name:

Amélia Pilar Rauter

Scientific Coordinator's e-mail:

aprauter@fc.ul.pt

Principal R&D Unit:

Centro de Química e Bioquímica (CQB)

Other R&D Units involved in the project:

Eli Lilly (UK)

Project keyword(s)

synthesis; carbohydrate; nucleoside; butyrylcholinesterase inhibition; selectivity; kinase inhibition; mechanisms of action; cancer; Alzheimer’s disease

Short abstract and comments

A lead series of nucleosides has been produced and their anticancer activity has been evaluated. Selectivity towards acetyl- or butyrylcholinesterase inhibition could be tuned by their structural features, easily established by synthesis. Structure optimization and mechanisms of action are currently under evaluation.

Potential uses/indications

Depending on nucleoside structural features, the compounds may be of use for Alzheimer’s disease patients or for cancer patients

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

“Diagnostic and Drug Discovery Initiative for Alzheimer’s Disease”, Industry-Academia Partnerships a

Last edited on

2016-11-21 18:05:05

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