Project title

New anticancer and potent butyrylcholinesterase purine nucleosides – their role and mechanism of action in brain and cancer

Scientific Coordinator's name:

Amélia Pilar Rauter

Scientific Coordinator's e-mail:

aprauter@fc.ul.pt

Principal R&D Unit:

Centro de Química e Bioquímica (CQB)

Other R&D Units involved in the project:

Eli Lilly (UK)

Project keyword(s)

synthesis; carbohydrate; nucleoside; butyrylcholinesterase inhibition; selectivity; kinase inhibition; mechanisms of action; cancer; Alzheimer’s disease

Short abstract and comments

A lead series of nucleosides has been produced and their anticancer activity has been evaluated. Selectivity towards acetyl- or butyrylcholinesterase inhibition could be tuned by their structural features, easily established by synthesis. Structure optimization and mechanisms of action are currently under evaluation.

Potential uses/indications

Depending on nucleoside structural features, the compounds may be of use for Alzheimer’s disease patients or for cancer patients