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New antimicrobial agents with new mechanisms of action – the quest to overcome antibiotic resistance

Faculdade de Ciências da Universidade de Lisboa
Project classification

Scientific area

1.4 Chemical sciences

Discipline(s)

Organic chemistry

Project description

Project title

New antimicrobial agents with new mechanisms of action – the quest to overcome antibiotic resistance

Scientific Coordinator's name:

Amélia Pilar Rauter

Scientific Coordinator's e-mail:

aprauter@fc.ul.pt

Principal R&D Unit:

Centro de Química e Bioquímica (CQB)

Other R&D Units involved in the project:

INSA (Instituto Nacional de Saúde Dr. Ricardo Jorge), CIPAN, BioforDrug (Italy)

Project keyword(s)

synthesis; carbohydrate; Bacillus anthracis; antibacterial agents; biophysical methods; cell membrane; mechanism of action

Short abstract and comments

A lead series of sugar-based antibacterial agents has been produced and preliminary studies of toxicity have been carried out. The antibacterial activity is bactericidal in nature, and the mechanism of action has been unraveled relying on the cytoplasmic membrane

Potential uses/indications

The potential uses are based on their application against microbial infection

Status

Concluded

Partner Status: Seeking Partners?

No

Grant number (QREN, FP7, Eureka, etc)

QREN SI I&DT [New drugs from sugars against infections by Bacillus species (FACIB) - Lisboa-01-0202-

Last edited on

2016-11-21 18:05:17

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