Scientific area
3.1 Basic medicine
Discipline(s)
Neurosciences (including psychophysiology)
Project title
Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury
Scientific Coordinator's name:
Monica Sousa
Scientific Coordinator's e-mail:
msousa@ibmc.up.pt
Principal R&D Unit:
Nerve Regeneration
Other R&D Units involved in the project:
Other R&D units involved in the project
Project keyword(s)
spinal cord injury, axonal regeneration
Short abstract and comments
The inability of axons to regenerate in the mature central nervous system (CNS) poses a major obstacle in the treatment of neurological disorders and CNS injury. As such, to date, therapeutic approaches aiming at promoting axonal regeneration following CNS disease/injury lead to disappointing functional recovery and remain a medical challenge. The short-term goals of this collaborative research are to elucidate cell-intrinsic mechanisms governing axon growth and regeneration in the CNS and to evaluate the translational outcome of the molecules identified in mouse and rat models of spinal cord injury. In the long term, our project will contribute to the development of therapeutic tools to promote axonal regeneration that may be transferred to clinical applications in a variety of neurological disorders and CNS injury.
Potential uses/indications
Find new therapeutic targets to promote axonal regeneration after injury
Status
Ongoing
Partner Status: Seeking Partners?
No
Grant number (QREN, FP7, Eureka, etc)
HMSP-ICT/0020/2010
Last edited on
2013-01-25 19:28:38