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Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury

IBMC - Institute for Molecular and Cell Biology
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Neurosciences (including psychophysiology)

Project description

Project title

Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury

Scientific Coordinator's name:

Monica Sousa

Scientific Coordinator's e-mail:

msousa@ibmc.up.pt

Principal R&D Unit:

Nerve Regeneration

Other R&D Units involved in the project:

Other R&D units involved in the project

Project keyword(s)

spinal cord injury, axonal regeneration

Short abstract and comments

The inability of axons to regenerate in the mature central nervous system (CNS) poses a major obstacle in the treatment of neurological disorders and CNS injury. As such, to date, therapeutic approaches aiming at promoting axonal regeneration following CNS disease/injury lead to disappointing functional recovery and remain a medical challenge. The short-term goals of this collaborative research are to elucidate cell-intrinsic mechanisms governing axon growth and regeneration in the CNS and to evaluate the translational outcome of the molecules identified in mouse and rat models of spinal cord injury. In the long term, our project will contribute to the development of therapeutic tools to promote axonal regeneration that may be transferred to clinical applications in a variety of neurological disorders and CNS injury.

Potential uses/indications

Find new therapeutic targets to promote axonal regeneration after injury

Status

Ongoing

Partner Status: Seeking Partners?

No

Grant number (QREN, FP7, Eureka, etc)

HMSP-ICT/0020/2010

Last edited on

2013-01-25 19:28:38

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