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Are microglia a new potential pharmacological target in amyotrophic lateral sclerosis (ALS)?

iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Neurosciences (including psychophysiology)

Project description

Project title

Are microglia a new potential pharmacological target in amyotrophic lateral sclerosis (ALS)?

Scientific Coordinator's name:

Dora Brites

Scientific Coordinator's e-mail:

dbrites@ff.ul.pt

Principal R&D Unit:

iMed.UL/FFUL

Other R&D Units involved in the project:

Department of Neuroscience, Mayo Clinic (Dpt. Neur/Mayo); Laboratorio de Neurodegeneración, Institut Pasteur de Montevideo (Neur/IPM)

Project keyword(s)

Chemoattractants; Spinal cord motor-neurons (MN); Microglia migration, phagocytosis and reactivity; Biomarkers of ALS and disease progression

Short abstract and comments

The project intends to identify factors produced by MN in ALS models that indicate neurodegeneration as well as structural changes caused by mSOD1G93A. Moreover, it is aimed to identify the changes produced by those soluble factors on microglia reactivity and corresponding phenotypes.

Potential uses/indications

Better knowledge on the pathophysiology of ALS, in particular microglia as contributors in the disease onset and progression, in order to find out determinants and targets that can be used for the development of new medicines to ALS.

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

PTDC/SAU-FAR/118787/2010 from FCT

Last edited on

2013-11-04 13:08:41

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