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Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neuronal dialogue in Alzheimer’s disease pathogenesis

iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Neurosciences (including psychophysiology)

Project description

Project title

Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neuronal dialogue in Alzheimer’s disease pathogenesis

Scientific Coordinator's name:

Dora Brites

Scientific Coordinator's e-mail:

dbrites@ff.ul.pt

Principal R&D Unit:

iMed.UL/FFUL

Other R&D Units involved in the project:

Institute of Biochemistry, Faculty of Medicine, and CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Project keyword(s)

Alzheimer´s disease; Neuron-microglia cross-talk; Ageing; Microglia senescence

Short abstract and comments

The project intends to identify which determinants (as candidate drug targets) cause the cross-talk impairment between neurons and microglia, in order to intervene in Alzheimer’s disease (AD) onset and progression.

Potential uses/indications

Better knowledge on the pathophysiology of AD, in particular microglia as contributors in the disease onset and progression, in order to find out determinants and targets that can be used for the development of new medicines to AD. In addition, it is expected to further identify determinants and biomarkers of vulnerabilities by ageing.

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

GEECD 2012

Last edited on

2013-11-04 13:00:57

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