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NanoPoliBiofilm - Polymeric therapeutic nanoparticles containing an antimicrobial agent: new opportunities for the development of anti-biofilm agents to treat prosthetic joint infections.

iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Toxicology
Pharmacology and pharmacy

Project description

Project title

NanoPoliBiofilm - Polymeric therapeutic nanoparticles containing an antimicrobial agent: new opportunities for the development of anti-biofilm agents to treat prosthetic joint infections.

Scientific Coordinator's name:

Ana Francisca Bettencourt

Scientific Coordinator's e-mail:

asimao@ff.ul.pt

Principal R&D Unit:

iMed.UL/FFUL

Other R&D Units involved in the project:

Charité – University Medicine Berlin, Center for Musculoskeletal Surgery

Project keyword(s)

polymeric nanoparticles; biofilm-infections; prosthetic joint infections; local-drug-delivery; release kinetics; biocompatibility

Short abstract and comments

PoliNanoBiofilm project seeks to develop novel polymeric-nanoparticles (NPs) with tailored release properties and high anti-biofilm Staphylococcus aureus activity for potential broad use as local drug delivery systems, in the context of prosthetic joint infections. Specifically, it explores biomedical polymers with different degradation rates that can be tailored to provide suitable anti-biofilm release profiles. Drug release profile from NPs is a major determinant in its anti-biofilm effect. Thus, assessment of antibiotic release data by kinetic models approaches is of paramount importance in the context of the project. Evaluation of NPs for their anti-biofilm activity by microcalorimetry assays and biocompatibility screening are also under evaluation.

Potential uses/indications

Potential broad use as local drug delivery systems in the context of prosthetic joint infections; set-up methodologies for nanoparticles antimicrobial and biocompatibility evaluation.

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

EXCL/CTM/NAN/0166/2012

Last edited on

2013-11-07 18:23:02

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