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Preventing Memory Loss in Alzheimer’s Disease: Underlying Mechanisms and Therapeutic Targets of Tauroursodeoxycholic Acid

iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Toxicology
Pharmacology and pharmacy
Neurosciences (including psychophysiology)

Project description

Project title

Preventing Memory Loss in Alzheimer’s Disease: Underlying Mechanisms and Therapeutic Targets of Tauroursodeoxycholic Acid

Scientific Coordinator's name:

Cecília Maria Pereira Rodrigues

Scientific Coordinator's e-mail:

cmprodrigues@ff.ul.pt

Principal R&D Unit:

iMed.UL/FFUL

Other R&D Units involved in the project:

University of Minnesota Medical School, Department of Medicine and Genetics, Cell Biology, and Development (UM) Catholic University of Leuven, Belgium (KULeuven)

Project keyword(s)

Amyloid-beta; APP/PS1 double transgenic; Neuroprotection; miRNAs

Short abstract and comments

Alzheimer’s disease is a neurodegenerative disease characterized by accumulation of toxic amyloid-beta in the frontal cortex and hippocampus, with progressive cognitive decline. However, little is known about the mechanisms that contribute to Abeta load in the vast majority of sporadic Alzheimer’s disease. This project aims at determining whether targeting signal transduction pathways and gene and protein networks in amyloid-beta metabolism by tauroursodeoxycholic acid can be used therapeutically to arrest the pathogenesis of Alzheimer’s disease.

Potential uses/indications

This project will increase our appreciation of the gene and protein networks that mediate Abeta metabolism and pathology, which will be crucial for developing novel and potent therapeutic approaches to overcome the current lack of successful therapies in Alzheimer’s disease.

Status

Ongoing

Partner Status: Seeking Partners?

No

Grant number (QREN, FP7, Eureka, etc)

PTDC/SAU-NMC/117877/2010

Last edited on

2013-11-04 13:02:11

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