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Towards malaria eradication. A novel approach for multi-targeting the parasite’s life cycle

iMed.ULisboa/ FFULisboa Research Institute for Medicines/ Faculdade de Farmácia, Universidade de Lisboa
Project classification

Scientific area

3.1 Basic medicine

Discipline(s)

Medicinal chemistry

Project description

Project title

Towards malaria eradication. A novel approach for multi-targeting the parasite’s life cycle

Scientific Coordinator's name:

Francisca da Conceição Lopes

Scientific Coordinator's e-mail:

fclopes@ff.ul.pt

Principal R&D Unit:

iMed.UL/FFUL

Other R&D Units involved in the project:

Instituto de Medicina Molecular (IMM/FM/UL); Centro de Neurociências e Biologia Celular (CNBC/UC)

Project keyword(s)

Antimalarials, Hybrid drugs, Peroxides, Blood stage, Liver stage

Short abstract and comments

The emergence and spread of multidrug-resistant Plasmodium falciparum, the causative agent of the most lethal form of human malaria, is still the major obstacle in the control of the disease. The central hypothesis of the project is that combining two chemotypes - each one targeting a specific stage of the parasite’s life cycle - in a single chemical entity, can lead to effective antimalarials capable of killing both the blood- and liver-stage parasites in order to obtain new tools for eradication campaigns of malaria.

Potential uses/indications

Chemical tools to study the biology of malaria infection; Dual acting antimalarial agents; multi-stage antimalarial agents.

Status

Ongoing

Partner Status: Seeking Partners?

Yes

Grant number (QREN, FP7, Eureka, etc)

PTDC/SAU-FAR/118459/2010

Last edited on

2013-11-04 13:16:09

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