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Bone biochemical and biomechanic integrated modeling: addressing remodeling, disease and therapy dynamics

INEGI - Institute of Science and Innovation in Mechanical and Industrial Engineering
Project classification

Scientific area

2.3 Mechanical engineering

Discipline(s)

Applied mechanics

Project description

Project title

Bone biochemical and biomechanic integrated modeling: addressing remodeling, disease and therapy dynamics

Scientific Coordinator's name:

Jorge Belinha

Scientific Coordinator's e-mail:

jorge.belinha@fe.up.pt

Principal R&D Unit:

Design and Experimental Validation Unit

Other R&D Units involved in the project:

Other R&D units involved in the project

Project keyword(s)

Advanced Discretization Methods, Bone tissue, cellular Remodelling, Biomechanics

Short abstract and comments

Collaborative Project with Instituto de Engenharia Mecânica (IDMEC-IST). Engineering is becoming a relevant research area to model complex diseases and optimize therapeutic regimes in a personalized way by fostering the improvement of diagnosis, prognosis and prevention. These factors have presently an indisputable social-economical impact worldwide, a fact that is driving a major effort towards multidisciplinary approaches to meet the challenges arising at the interface of engineering with the life sciences and promoting the 4P Medicine: Predictive, Preventive, Personalized and Participatory. This project is focused on bone remodeling processes and diseases, with the goal of developing novel models that integrate knowledge from bone physiology and its biochemical environment, biomechanics and geometric regulations. These theoretical and computational models will be enriched with pharmacokinetic/pharmacodynamics (PK/PD) of the drugs usually administered for bone diseases such as osteoporosis, bone metastases and hyperparathyroidism. The team includes several groups with experience in several aspects of bone models, such as biochemical regulations (CSI-IDMEC), biomechanical response of bone to mechanical stimuli at different bone scales, from apparent density to cellular level (CPM-IDMEC), and bone tissue remodeling analysis using advanced discretization meshless techniques and construction of computational models from medical images (INEGI).

Potential uses/indications

The ultimate goal is to have a spatiotemporal model that can replicate the biomechanical and biochemical processes involved in bone remodeling, at its different scales, both in healthy and pathological states, and serve as a clinical decision support system for the design of therapeutic regimes and prognostic assessment.

Status

Ongoing

Partner Status: Seeking Partners?

No

Grant number (QREN, FP7, Eureka, etc)

UID/EMS/50022/2013 (funding provided by the inter-institutional projects from LAETA)

Last edited on

2016-05-03 12:21:17

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