Project title

The simulation of the remodelling and regeneration process of bone tissue: a multiscale meshless approach

Scientific Coordinator's name:

Jorge Belinha

Scientific Coordinator's e-mail:

jorge.belinha@fe.up.pt

Principal R&D Unit:

Design and Experimental Validation Unit

Other R&D Units involved in the project:

Other R&D units involved in the project

Project keyword(s)

Meshless Methods, Bone tissue, Remodelling, Biomechanics

Short abstract and comments

The bone is a living dynamic biomaterial tissue active during its life time that possesses relevant structural properties and a remarkable remodelling capacity. Being medical science evolving to individualized solutions, dictated by the distinct physiology of each patient, this study will allow to predict the healing time and designing suitable implants for the patient unique bone properties, obtained by computational tomography(CT) or Xray images, improving patient life quality in a bone healing process, due fracture/implants. First, it is developed a phenomenological bone tissue material law capable to correlate apparent density with the mechanical properties. Afterwards, this study will focus in the remodelling analysis of the trabecular bone tissue structure using a meshless method. Then, it will be incorporated in the developed software the bone tissue regeneration process, which is the product of a complex cellular sequence regulated by mechanobiological stimuli. Finally, real clinical cases will be simulated with the developed software.

Potential uses/indications

The final developed software will help to understand the bone morphological evolution and to develop individualized therapy protocols, maximizing the treatment effectiveness.